Publications 2016-2019
Monasterium Laboratory highlights (blue)
2019
(2019) Alam, M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R. Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo. J Invest Dermatol 139, 1593-1596. https://doi.org/10.1016/j.jid.2018.12.022
(2019) Alam, M, Bertolini M, Gherardini J, Keren A, Ponce L, Cheret J, Alenfall J, Duner P, Nilsson AH, Gilhar A, Paus R. An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. Br J Dermatol. https://doi.org/10.1111/bjd.18479
(2019) Alam, M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F. Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything? Dermatol Surg 45, 557-565. https://doi.org/10.1097/DSS.0000000000001748
(2019) Bray ER, Cheret J, Yosipovitch G, Paus R. Schwann cells as underestimated, major players in human skin physiology and pathology. Exp Dermatol (in press). https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14060
(2019) Bertolini, M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo. Int J Cosmet Sci. https://doi.org/10.1111/ics.12589
(2019) Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage. J Eur Acad Dermatol Vernereol (in press). https://www.ncbi.nlm.nih.gov/pubmed/31774585
(2019) Clayton, RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X. Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis. Br J Dermatol 181, 677-690. https://doi.org/10.1111/bjd.17981
(2019) Freites-Martinez, A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia. JAMA Dermatol 155, 724-728. https://doi.org/10.1001/jamadermatol.2018.5071
(2019) Freites-Martinez, A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME. Hair disorders in patients with cancer. J Am Acad Dermatol 80, 1179-1196. https://doi.org/10.1016/j.jaad.2018.03.055
(2019) Freites-Martinez, A, Shapiro J, van den Hurk C, Goldfarb S, Jimenez JJ, Rossi AM, Paus R, Lacouture ME. Hair disorders in cancer survivors. J Am Acad Dermatol 80, 1199-1213. https://doi.org/10.1016/j.jaad.2018.03.056
(2019) Gao, Q, Zhou G, Lin SJ, Paus R, Yue Z. How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models. Exp Dermatol 28, 413-418. https://doi.org/10.1111/exd.13846
(2019) Gherardini, J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M. Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine. Int J Cosmet Sci 41, 164-182. https://doi.org/10.1111/ics.12521
(2019) Gilhar, A, Britva RL, Keren A, Paus R. Frontiers in alopecia areata pathobiology research. J Allergy Clin Immunol. https://doi.org/10.1016/j.jaci.2019.08.035
(2019) Gilhar, A, Keren A, Paus R. JAK inhibitors and alopecia areata. Lancet 393, 318-319. https://doi.org/10.1016/S0140-6736(18)32987-8
(2019) Gkogkolou, P, Sarna M, Sarna T, Paus R, Luger TA, Bohm M. Protection of glucotoxicity by a tripeptide derivative of alpha-melanocyte-stimulating hormone in human epidermal keratinocytes. Br J Dermatol 180, 836-848. https://doi.org/10.1111/bjd.17125
(2019) Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease. PloS One. Jul 5, 14(7). https://www.ncbi.nlm.nih.gov/pubmed/31277078
(2019) Hardman, JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. Human Perifollicular Macrophages Undergo Apoptosis, Express Wnt Ligands and Switch their Polarization during Catagen. J Invest Dermatol. https://doi.org/10.1016/j.jid.2019.04.026
(2019) Harries, M, Imanishi H, Paus R. Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias. J Am Acad Dermatol 80, e165-e166. https://doi.org/10.1016/j.jaad.2018.12.055
(2019) Hawkshaw, NJ, Hardman JA, Alam M, Jimenez F, Paus R. Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. Br J Dermatol. https://doi.org/10.1111/bjd.18356
(2019) Hundt, JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo. Skin Pharmacol Physiol, 1-5. https://doi.org/10.1159/000501729
(2019) Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. J Invest Dermatol (in press) https://www.ncbi.nlm.nih.gov/pubmed/31730764
(2019) Laufer Britva, R, Keren A, Paus R, Gilhar A. Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata. Br J Dermatol. https://doi.org/10.1111/bjd.18264
(2019) Lehmann, J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J. Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo. Br J Dermatol 180, e141. https://doi.org/10.1111/bjd.17518
(2019) Leon, A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G. Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis. Exp Dermatol. https://doi.org/10.1111/exd.13947
(2019) Liao, T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R. Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo. Arch Dermatol Res 311, 325-330. https://doi.org/10.1007/s00403-019-01889-x
(2019) Muneeb, F, Hardman JA, Paus R. Hair growth control by innate immunocytes: Perifollicular macrophages revisited. Exp Dermatol 28, 425-431. https://doi.org/10.1111/exd.13922
(2019) Nasir, NAM, Paus R, Ansell DM. Fluorescent cell tracer dye permits real-time assessment of re-epithelialization in a serum-free ex vivo human skin wound assay. Wound Repair Regen 27, 126-133. https://doi.org/10.1111/wrr.12688
(2019) Nicu, C, Hardman JA, Pople J, Paus R. Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? Exp Dermatol 28, 432-435. https://doi.org/10.1111/exd.13904
(2019) Purba, TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. EMBO Mol Med 11, e11031. https://doi.org/10.15252/emmm.201911031
(2019) Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. Exp. Dermatol (in press). https://www.ncbi.nlm.nih.gov/pubmed/31769892
(2019) Smart, E, Farjo N, Farjo B, Haslam IS, Paus R. Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage. J Dermatol Sci 95, 44-47. https://doi.org/10.1016/j.jdermsci.2019.06.003
(2019) Szabo, IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG. TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro. J Invest Dermatol 139, 1385-1388. https://doi.org/10.1016/j.jid.2018.11.020
(2019) Szabo, IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. The Phytocannabinoid (-)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects. J Invest Dermatol. https://doi.org/10.1016/j.jid.2019.07.690
(2019) Toson, P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. Model-based approach to the design of pharmaceutical roller-compaction processes. Int J Pharm X 1, 100005. https://doi.org/10.1016/j.ijpx.2019.100005
(2019) Wikramanayake, TC, Borda LJ, Miteva M, Paus R. Seborrheic dermatitis-Looking beyond Malassezia. Exp Dermatol 28, 991-1001. https://doi.org/10.1111/exd.14006
(2019) Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways. J Dermatol Sci (in press) https://www.ncbi.nlm.nih.gov/pubmed/31718896
(2019) Zhang, GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R. Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo. PLoS One 14, e0212659. https://doi.org/10.1371/journal.pone.0212659
2018
(2018) Abarca-Buis, RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration. Differentiation 99, 10-20. https://doi.org/10.1016/j.diff.2017.12.001
(2018) Alam, M, Hernandez I, Paus R, Jimenez F. Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling. Br J Dermatol 178, e396. https://doi.org/10.1111/bjd.16569
(2018) Bertolini, M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. Bridging the "Dead Hair"-"Live Follicle" Divide in Applied Hair Research. J Cosmet Sci 69, 315-322. https://www.scconline.org/dead-hair-live-follicle/
(2018) Cheng, JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep 25, 871-883. https://doi.org/10.1016/j.celrep.2018.09.006
(2018) Cheret, J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. Olfactory receptor OR2AT4 regulates human hair growth. Nat Commun 9, 3624. https://doi.org/10.1038/s41467-018-05973-0
(2018) Dobreva, A, Paus R, Cogan NG. Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. Math Med Biol 35, 387-407. https://doi.org/10.1093/imammb/dqx009
(2018) Foster, AR, Nicu C, Schneider MR, Hinde E, Paus R. Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Arch Dermatol Res 310, 453-462. https://doi.org/10.1007/s00403-018-1831-y
(2018) Ghraieb, A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. J Autoimmun 91, 61-72. https://doi.org/10.1016/j.jaut.2018.04.001
(2018) Harries, MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases. Trends Mol Med 24, 435-448. https://doi.org/10.1016/j.molmed.2018.03.007
(2018) Haslam, IS, Hardman JA, Paus R. Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo. J Invest Dermatol 138, 1420-1422. https://doi.org/10.1016/j.jid.2017.12.019
(2018) Hawkshaw, NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biol 16, e2003705. https://doi.org/10.1371/journal.pbio.2003705
(2018) Hernandez, I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. J Am Acad Dermatol 79, 558-559. https://doi.org/10.1016/j.jaad.2018.02.009
(2018) Imanishi, H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R. Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris. J Invest Dermatol 138, 511-519. https://doi.org/10.1016/j.jid.2017.09.047
(2018) Jadkauskaite, L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. J Allergy Clin Immunol 142, 1331-1333 e1338. https://doi.org/10.1016/j.jaci.2018.04.039
(2018) Jimenez, F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. An efficient method for eccrine gland isolation from human scalp. Exp Dermatol 27, 678-681. https://doi.org/10.1111/exd.13505
(2018) Keren, A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin. J Allergy Clin Immunol 142, 305-308 e306. https://doi.org/10.1016/j.jaci.2018.02.015
(2018) Krieger, K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types. J Invest Dermatol 138, 256-264. https://doi.org/10.1016/j.jid.2017.08.042
(2018) Langan, EA, Fink T, Paus R. Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding? Arch Dermatol Res 310, 833-841. https://doi.org/10.1007/s00403-018-1864-2
(2018) Langan, EA, Hinde E, Paus R. Prolactin as a candidate sebotrop(h)ic hormone? Exp Dermatol 27, 729-736. https://doi.org/10.1111/exd.13545
(2018) Natsumi, A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D. Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis? J Histochem Cytochem 66, 847-862. https://doi.org/10.1369/0022155418782693
(2018) Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol 27, 589-602. https://doi.org/10.1111/exd.13549
(2018) Parodi, C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B. Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture. PLoS Biol 16, e2002864. https://doi.org/10.1371/journal.pbio.2002864
(2018) Paus R, Bulfone-Paus S, Bertolini M. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management. J Investig Dermatol Symp Proc 19, S12-S17. https://doi.org/10.1016/j.jisp.2017.10.014
(2018) Poblet, E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue. Br J Dermatol 178, 1163-1172. https://doi.org/10.1111/bjd.16436
(2018) Purba, TS, Marsh J, Ng'andu K, Kurinna S, Paus R. Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry. Biotechniques 65, 97-100. https://doi.org/10.2144/btn-2018-0025
(2018) Ramot, Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R. Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium. J Invest Dermatol 138, 1656-1659. https://doi.org/10.1016/j.jid.2018.01.033
(2018) Ramot, Y, Olah A, Paus R. Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids? Br J Dermatol 178, 1469. https://doi.org/10.1111/bjd.16570
(2018) Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex. Am J Hum Genet 103, 777-785. https://doi.org/10.1016/j.ajhg.2018.09.011
(2018) Rudyak, SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA. Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response. Biochem Biophys Res Commun 506, 854-861. https://doi.org/10.1016/j.bbrc.2018.10.126
(2018) Sardella, C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. J Invest Dermatol 138, 500-510. https://doi.org/10.1016/j.jid.2017.09.024
(2018) Slominski, AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions. J Invest Dermatol 138, 490-499. https://doi.org/10.1016/j.jid.2017.10.025
(2018) Slominski, AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. How UV Light Touches the Brain and Endocrine System Through Skin, and Why. Endocrinology 159, 1992-2007. https://doi.org/10.1210/en.2017-03230
(2018) Zhou, L, Zhang X, Paus R, Lu Z. The renaissance of human skin organ culture: A critical reappraisal. Differentiation 104, 22-35. https://doi.org/10.1016/j.diff.2018.10.002
2017
(2017) Ali, N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell 169, 1119-1129 e1111. https://doi.org/10.1016/j.cell.2017.05.002
(2017) Bertolini, M, Rossi A, Paus R. Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata? Br J Dermatol 176, 1106. https://doi.org/10.1111/bjd.15288
(2017) Haslam, IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition. J Invest Dermatol 137, 295-304. https://doi.org/10.1016/j.jid.2016.08.035
(2017) Heilmann-Heimbach, S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun 8, 14694. https://doi.org/10.1038/ncomms14694
(2017) Jadkauskaite, L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? Bioessays 39. https://doi.org/10.1002/bies.201700029
(2017) Jumper, N, Hodgkinson T, Paus R, Bayat A. Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology. PLoS One 12, e0172955. https://doi.org/10.1371/journal.pone.0172955
(2017) Jumper, N, Hodgkinson T, Paus R, Bayat A. A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling. Acta Derm Venereol 97, 675-684. https://doi.org/10.2340/00015555-2587
(2017) Oelert, T, Gilhar A, Paus R. T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. Exp Dermatol 26, 529-531. https://doi.org/10.1111/exd.13238
(2017) Purba, TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus R. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. Eur J Cell Biol 96, 632-641. https://doi.org/10.1016/j.ejcb.2017.03.011
(2017) Purba, TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2. Sci Rep 7, 15197. https://doi.org/10.1038/s41598-017-15038-9
(2017) Sebastian, A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation. J Invest Dermatol 137, 737-747. https://doi.org/10.1016/j.jid.2016.09.038
(2017) Stojadinovic, O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling. Heliyon 3, e00309. https://doi.org/10.1016/j.heliyon.2017.e00309
(2017) Tsai, T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol 26, 58-65. https://doi.org/10.1111/exd.13132
(2017) Xie, G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. E-Cadherin-Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis. J Invest Dermatol 137, 1731-1739. https://doi.org/10.1016/j.jid.2017.03.036
2016
(2016) Bagabir, RA, Syed F, Shenjere P, Paus R, Bayat A. Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue. J Invest Dermatol 136, 2319-2323. https://doi.org/10.1016/j.jid.2016.06.623
(2016) Bertolini, M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. Br J Dermatol 175, 531-541. https://doi.org/10.1111/bjd.14645
(2016) Dahlhoff, M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development 143, 1823-1831. https://doi.org/10.1242/dev.132753
(2016) Fleger-Weckmann, A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol 56, 42-56. https://doi.org/10.1016/j.matbio.2016.05.002
(2016) Garcin, CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization. Stem Cells 34, 1377-1385. https://doi.org/10.1002/stem.2289
(2016) Gilhar, A, Schrum AG, Etzioni A, Waldmann H, Paus R. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. Autoimmun Rev 15, 726-735. https://doi.org/10.1016/j.autrev.2016.03.008
(2016) Harries, M, Tosti A, Bergfeld W, Blume-Peytavi U, Shapiro J, Lutz G, Messenger A, Sinclair R, Paus R. Towards a consensus on how to diagnose and quantify female pattern hair loss - The 'Female Pattern Hair Loss Severity Index (FPHL-SI)'. J Eur Acad Dermatol Venereol 30, 667-676. https://doi.org/10.1111/jdv.13455
(2016) Heilmann-Heimbach, S, Hochfeld LM, Paus R, Nothen MM. Hunting the genes in male-pattern alopecia: how important are they, how close are we and what will they tell us? Exp Dermatol 25, 251-257. https://doi.org/10.1111/exd.12965
(2016) Jumper, N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease. J Invest Dermatol 136, 1500-1512. https://doi.org/10.1016/j.jid.2016.03.022
(2016) Jumper, N, Paus R, Bayat A. An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target. Plast Reconstr Surg Glob Open 4, e601. https://doi.org/10.1097/GOX.0000000000000589
(2016) Liao, C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis. J Invest Dermatol 136, 680-689. https://doi.org/10.1016/j.jid.2015.12.021
(2016) O'Neill, CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays 38, 1167-1176. https://doi.org/10.1002/bies.201600008
(2016) Oh, JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A Guide to Studying Human Hair Follicle Cycling In Vivo. J Invest Dermatol 136, 34-44. https://doi.org/10.1038/JID.2015.354
(2016) Olah, A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo. J Invest Dermatol 136, 1711-1714. https://doi.org/10.1016/j.jid.2016.03.033
(2016) Paus R. Exploring the "brain-skin connection": Leads and lessons from the hair follicle. Curr Res Transl Med 64, 207-214. https://doi.org/10.1016/j.retram.2016.10.003
(2016) Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. Biology of the eyelash hair follicle: an enigma in plain sight. Br J Dermatol 174, 741-752. https://doi.org/10.1111/bjd.14217
(2016) Peled, A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E. Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis. PLoS Genet 12, e1006369. https://doi.org/10.1371/journal.pgen.1006369
(2016) Poblet, E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Exp Dermatol 25, 149-150. https://doi.org/10.1111/exd.12889
(2016) Purba, TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. A primer for studying cell cycle dynamics of the human hair follicle. Exp Dermatol 25, 663-668. https://doi.org/10.1111/exd.13046
(2016) Tomann, P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. Development 143, 1512-1522. https://doi.org/10.1242/dev.130898
(2016) Vidali, S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis. J Invest Dermatol 136, 2003-2012. https://doi.org/10.1016/j.jid.2016.05.118
2019
(2019) Alam, M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R. Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo. J Invest Dermatol 139, 1593-1596. https://doi.org/10.1016/j.jid.2018.12.022
(2019) Alam, M, Bertolini M, Gherardini J, Keren A, Ponce L, Cheret J, Alenfall J, Duner P, Nilsson AH, Gilhar A, Paus R. An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. Br J Dermatol. https://doi.org/10.1111/bjd.18479
(2019) Alam, M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F. Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything? Dermatol Surg 45, 557-565. https://doi.org/10.1097/DSS.0000000000001748
(2019) Bray ER, Cheret J, Yosipovitch G, Paus R. Schwann cells as underestimated, major players in human skin physiology and pathology. Exp Dermatol (in press). https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14060
(2019) Bertolini, M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo. Int J Cosmet Sci. https://doi.org/10.1111/ics.12589
(2019) Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage. J Eur Acad Dermatol Vernereol (in press). https://www.ncbi.nlm.nih.gov/pubmed/31774585
(2019) Clayton, RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X. Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis. Br J Dermatol 181, 677-690. https://doi.org/10.1111/bjd.17981
(2019) Freites-Martinez, A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia. JAMA Dermatol 155, 724-728. https://doi.org/10.1001/jamadermatol.2018.5071
(2019) Freites-Martinez, A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME. Hair disorders in patients with cancer. J Am Acad Dermatol 80, 1179-1196. https://doi.org/10.1016/j.jaad.2018.03.055
(2019) Freites-Martinez, A, Shapiro J, van den Hurk C, Goldfarb S, Jimenez JJ, Rossi AM, Paus R, Lacouture ME. Hair disorders in cancer survivors. J Am Acad Dermatol 80, 1199-1213. https://doi.org/10.1016/j.jaad.2018.03.056
(2019) Gao, Q, Zhou G, Lin SJ, Paus R, Yue Z. How chemotherapy and radiotherapy damage the tissue: Comparative biology lessons from feather and hair models. Exp Dermatol 28, 413-418. https://doi.org/10.1111/exd.13846
(2019) Gherardini, J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M. Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine. Int J Cosmet Sci 41, 164-182. https://doi.org/10.1111/ics.12521
(2019) Gilhar, A, Britva RL, Keren A, Paus R. Frontiers in alopecia areata pathobiology research. J Allergy Clin Immunol. https://doi.org/10.1016/j.jaci.2019.08.035
(2019) Gilhar, A, Keren A, Paus R. JAK inhibitors and alopecia areata. Lancet 393, 318-319. https://doi.org/10.1016/S0140-6736(18)32987-8
(2019) Gkogkolou, P, Sarna M, Sarna T, Paus R, Luger TA, Bohm M. Protection of glucotoxicity by a tripeptide derivative of alpha-melanocyte-stimulating hormone in human epidermal keratinocytes. Br J Dermatol 180, 836-848. https://doi.org/10.1111/bjd.17125
(2019) Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease. PloS One. Jul 5, 14(7). https://www.ncbi.nlm.nih.gov/pubmed/31277078
(2019) Hardman, JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. Human Perifollicular Macrophages Undergo Apoptosis, Express Wnt Ligands and Switch their Polarization during Catagen. J Invest Dermatol. https://doi.org/10.1016/j.jid.2019.04.026
(2019) Harries, M, Imanishi H, Paus R. Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias. J Am Acad Dermatol 80, e165-e166. https://doi.org/10.1016/j.jaad.2018.12.055
(2019) Hawkshaw, NJ, Hardman JA, Alam M, Jimenez F, Paus R. Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. Br J Dermatol. https://doi.org/10.1111/bjd.18356
(2019) Hundt, JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo. Skin Pharmacol Physiol, 1-5. https://doi.org/10.1159/000501729
(2019) Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. J Invest Dermatol (in press) https://www.ncbi.nlm.nih.gov/pubmed/31730764
(2019) Laufer Britva, R, Keren A, Paus R, Gilhar A. Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata. Br J Dermatol. https://doi.org/10.1111/bjd.18264
(2019) Lehmann, J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J. Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo. Br J Dermatol 180, e141. https://doi.org/10.1111/bjd.17518
(2019) Leon, A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G. Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis. Exp Dermatol. https://doi.org/10.1111/exd.13947
(2019) Liao, T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R. Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo. Arch Dermatol Res 311, 325-330. https://doi.org/10.1007/s00403-019-01889-x
(2019) Muneeb, F, Hardman JA, Paus R. Hair growth control by innate immunocytes: Perifollicular macrophages revisited. Exp Dermatol 28, 425-431. https://doi.org/10.1111/exd.13922
(2019) Nasir, NAM, Paus R, Ansell DM. Fluorescent cell tracer dye permits real-time assessment of re-epithelialization in a serum-free ex vivo human skin wound assay. Wound Repair Regen 27, 126-133. https://doi.org/10.1111/wrr.12688
(2019) Nicu, C, Hardman JA, Pople J, Paus R. Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? Exp Dermatol 28, 432-435. https://doi.org/10.1111/exd.13904
(2019) Purba, TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. EMBO Mol Med 11, e11031. https://doi.org/10.15252/emmm.201911031
(2019) Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. Exp. Dermatol (in press). https://www.ncbi.nlm.nih.gov/pubmed/31769892
(2019) Smart, E, Farjo N, Farjo B, Haslam IS, Paus R. Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage. J Dermatol Sci 95, 44-47. https://doi.org/10.1016/j.jdermsci.2019.06.003
(2019) Szabo, IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG. TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro. J Invest Dermatol 139, 1385-1388. https://doi.org/10.1016/j.jid.2018.11.020
(2019) Szabo, IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. The Phytocannabinoid (-)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects. J Invest Dermatol. https://doi.org/10.1016/j.jid.2019.07.690
(2019) Toson, P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. Model-based approach to the design of pharmaceutical roller-compaction processes. Int J Pharm X 1, 100005. https://doi.org/10.1016/j.ijpx.2019.100005
(2019) Wikramanayake, TC, Borda LJ, Miteva M, Paus R. Seborrheic dermatitis-Looking beyond Malassezia. Exp Dermatol 28, 991-1001. https://doi.org/10.1111/exd.14006
(2019) Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways. J Dermatol Sci (in press) https://www.ncbi.nlm.nih.gov/pubmed/31718896
(2019) Zhang, GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R. Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo. PLoS One 14, e0212659. https://doi.org/10.1371/journal.pone.0212659
2018
(2018) Abarca-Buis, RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration. Differentiation 99, 10-20. https://doi.org/10.1016/j.diff.2017.12.001
(2018) Alam, M, Hernandez I, Paus R, Jimenez F. Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling. Br J Dermatol 178, e396. https://doi.org/10.1111/bjd.16569
(2018) Bertolini, M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. Bridging the "Dead Hair"-"Live Follicle" Divide in Applied Hair Research. J Cosmet Sci 69, 315-322. https://www.scconline.org/dead-hair-live-follicle/
(2018) Cheng, JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep 25, 871-883. https://doi.org/10.1016/j.celrep.2018.09.006
(2018) Cheret, J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. Olfactory receptor OR2AT4 regulates human hair growth. Nat Commun 9, 3624. https://doi.org/10.1038/s41467-018-05973-0
(2018) Dobreva, A, Paus R, Cogan NG. Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. Math Med Biol 35, 387-407. https://doi.org/10.1093/imammb/dqx009
(2018) Foster, AR, Nicu C, Schneider MR, Hinde E, Paus R. Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Arch Dermatol Res 310, 453-462. https://doi.org/10.1007/s00403-018-1831-y
(2018) Ghraieb, A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. J Autoimmun 91, 61-72. https://doi.org/10.1016/j.jaut.2018.04.001
(2018) Harries, MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases. Trends Mol Med 24, 435-448. https://doi.org/10.1016/j.molmed.2018.03.007
(2018) Haslam, IS, Hardman JA, Paus R. Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo. J Invest Dermatol 138, 1420-1422. https://doi.org/10.1016/j.jid.2017.12.019
(2018) Hawkshaw, NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biol 16, e2003705. https://doi.org/10.1371/journal.pbio.2003705
(2018) Hernandez, I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. J Am Acad Dermatol 79, 558-559. https://doi.org/10.1016/j.jaad.2018.02.009
(2018) Imanishi, H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R. Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris. J Invest Dermatol 138, 511-519. https://doi.org/10.1016/j.jid.2017.09.047
(2018) Jadkauskaite, L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. J Allergy Clin Immunol 142, 1331-1333 e1338. https://doi.org/10.1016/j.jaci.2018.04.039
(2018) Jimenez, F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. An efficient method for eccrine gland isolation from human scalp. Exp Dermatol 27, 678-681. https://doi.org/10.1111/exd.13505
(2018) Keren, A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin. J Allergy Clin Immunol 142, 305-308 e306. https://doi.org/10.1016/j.jaci.2018.02.015
(2018) Krieger, K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types. J Invest Dermatol 138, 256-264. https://doi.org/10.1016/j.jid.2017.08.042
(2018) Langan, EA, Fink T, Paus R. Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding? Arch Dermatol Res 310, 833-841. https://doi.org/10.1007/s00403-018-1864-2
(2018) Langan, EA, Hinde E, Paus R. Prolactin as a candidate sebotrop(h)ic hormone? Exp Dermatol 27, 729-736. https://doi.org/10.1111/exd.13545
(2018) Natsumi, A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D. Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis? J Histochem Cytochem 66, 847-862. https://doi.org/10.1369/0022155418782693
(2018) Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol 27, 589-602. https://doi.org/10.1111/exd.13549
(2018) Parodi, C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B. Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture. PLoS Biol 16, e2002864. https://doi.org/10.1371/journal.pbio.2002864
(2018) Paus R, Bulfone-Paus S, Bertolini M. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management. J Investig Dermatol Symp Proc 19, S12-S17. https://doi.org/10.1016/j.jisp.2017.10.014
(2018) Poblet, E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue. Br J Dermatol 178, 1163-1172. https://doi.org/10.1111/bjd.16436
(2018) Purba, TS, Marsh J, Ng'andu K, Kurinna S, Paus R. Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry. Biotechniques 65, 97-100. https://doi.org/10.2144/btn-2018-0025
(2018) Ramot, Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R. Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium. J Invest Dermatol 138, 1656-1659. https://doi.org/10.1016/j.jid.2018.01.033
(2018) Ramot, Y, Olah A, Paus R. Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids? Br J Dermatol 178, 1469. https://doi.org/10.1111/bjd.16570
(2018) Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex. Am J Hum Genet 103, 777-785. https://doi.org/10.1016/j.ajhg.2018.09.011
(2018) Rudyak, SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA. Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response. Biochem Biophys Res Commun 506, 854-861. https://doi.org/10.1016/j.bbrc.2018.10.126
(2018) Sardella, C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. J Invest Dermatol 138, 500-510. https://doi.org/10.1016/j.jid.2017.09.024
(2018) Slominski, AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions. J Invest Dermatol 138, 490-499. https://doi.org/10.1016/j.jid.2017.10.025
(2018) Slominski, AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. How UV Light Touches the Brain and Endocrine System Through Skin, and Why. Endocrinology 159, 1992-2007. https://doi.org/10.1210/en.2017-03230
(2018) Zhou, L, Zhang X, Paus R, Lu Z. The renaissance of human skin organ culture: A critical reappraisal. Differentiation 104, 22-35. https://doi.org/10.1016/j.diff.2018.10.002
2017
(2017) Ali, N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell 169, 1119-1129 e1111. https://doi.org/10.1016/j.cell.2017.05.002
(2017) Bertolini, M, Rossi A, Paus R. Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata? Br J Dermatol 176, 1106. https://doi.org/10.1111/bjd.15288
(2017) Haslam, IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition. J Invest Dermatol 137, 295-304. https://doi.org/10.1016/j.jid.2016.08.035
(2017) Heilmann-Heimbach, S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun 8, 14694. https://doi.org/10.1038/ncomms14694
(2017) Jadkauskaite, L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? Bioessays 39. https://doi.org/10.1002/bies.201700029
(2017) Jumper, N, Hodgkinson T, Paus R, Bayat A. Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology. PLoS One 12, e0172955. https://doi.org/10.1371/journal.pone.0172955
(2017) Jumper, N, Hodgkinson T, Paus R, Bayat A. A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling. Acta Derm Venereol 97, 675-684. https://doi.org/10.2340/00015555-2587
(2017) Oelert, T, Gilhar A, Paus R. T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. Exp Dermatol 26, 529-531. https://doi.org/10.1111/exd.13238
(2017) Purba, TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus R. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. Eur J Cell Biol 96, 632-641. https://doi.org/10.1016/j.ejcb.2017.03.011
(2017) Purba, TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2. Sci Rep 7, 15197. https://doi.org/10.1038/s41598-017-15038-9
(2017) Sebastian, A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation. J Invest Dermatol 137, 737-747. https://doi.org/10.1016/j.jid.2016.09.038
(2017) Stojadinovic, O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling. Heliyon 3, e00309. https://doi.org/10.1016/j.heliyon.2017.e00309
(2017) Tsai, T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol 26, 58-65. https://doi.org/10.1111/exd.13132
(2017) Xie, G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. E-Cadherin-Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis. J Invest Dermatol 137, 1731-1739. https://doi.org/10.1016/j.jid.2017.03.036
2016
(2016) Bagabir, RA, Syed F, Shenjere P, Paus R, Bayat A. Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue. J Invest Dermatol 136, 2319-2323. https://doi.org/10.1016/j.jid.2016.06.623
(2016) Bertolini, M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. Br J Dermatol 175, 531-541. https://doi.org/10.1111/bjd.14645
(2016) Dahlhoff, M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development 143, 1823-1831. https://doi.org/10.1242/dev.132753
(2016) Fleger-Weckmann, A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol 56, 42-56. https://doi.org/10.1016/j.matbio.2016.05.002
(2016) Garcin, CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization. Stem Cells 34, 1377-1385. https://doi.org/10.1002/stem.2289
(2016) Gilhar, A, Schrum AG, Etzioni A, Waldmann H, Paus R. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. Autoimmun Rev 15, 726-735. https://doi.org/10.1016/j.autrev.2016.03.008
(2016) Harries, M, Tosti A, Bergfeld W, Blume-Peytavi U, Shapiro J, Lutz G, Messenger A, Sinclair R, Paus R. Towards a consensus on how to diagnose and quantify female pattern hair loss - The 'Female Pattern Hair Loss Severity Index (FPHL-SI)'. J Eur Acad Dermatol Venereol 30, 667-676. https://doi.org/10.1111/jdv.13455
(2016) Heilmann-Heimbach, S, Hochfeld LM, Paus R, Nothen MM. Hunting the genes in male-pattern alopecia: how important are they, how close are we and what will they tell us? Exp Dermatol 25, 251-257. https://doi.org/10.1111/exd.12965
(2016) Jumper, N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease. J Invest Dermatol 136, 1500-1512. https://doi.org/10.1016/j.jid.2016.03.022
(2016) Jumper, N, Paus R, Bayat A. An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target. Plast Reconstr Surg Glob Open 4, e601. https://doi.org/10.1097/GOX.0000000000000589
(2016) Liao, C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis. J Invest Dermatol 136, 680-689. https://doi.org/10.1016/j.jid.2015.12.021
(2016) O'Neill, CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays 38, 1167-1176. https://doi.org/10.1002/bies.201600008
(2016) Oh, JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A Guide to Studying Human Hair Follicle Cycling In Vivo. J Invest Dermatol 136, 34-44. https://doi.org/10.1038/JID.2015.354
(2016) Olah, A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo. J Invest Dermatol 136, 1711-1714. https://doi.org/10.1016/j.jid.2016.03.033
(2016) Paus R. Exploring the "brain-skin connection": Leads and lessons from the hair follicle. Curr Res Transl Med 64, 207-214. https://doi.org/10.1016/j.retram.2016.10.003
(2016) Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. Biology of the eyelash hair follicle: an enigma in plain sight. Br J Dermatol 174, 741-752. https://doi.org/10.1111/bjd.14217
(2016) Peled, A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E. Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis. PLoS Genet 12, e1006369. https://doi.org/10.1371/journal.pgen.1006369
(2016) Poblet, E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Exp Dermatol 25, 149-150. https://doi.org/10.1111/exd.12889
(2016) Purba, TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. A primer for studying cell cycle dynamics of the human hair follicle. Exp Dermatol 25, 663-668. https://doi.org/10.1111/exd.13046
(2016) Tomann, P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. Development 143, 1512-1522. https://doi.org/10.1242/dev.130898
(2016) Vidali, S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis. J Invest Dermatol 136, 2003-2012. https://doi.org/10.1016/j.jid.2016.05.118
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